Main characters

Sam B (voiced by Phil LaMarr), a one-hit wonder rap star from New Orleans. He was booked by the Royal Palms Resort to perform his well-known song "Who Do You Voodoo" at a high profile hotel party. He gladly took the chance to play this gig. Once strong, self-confident and proud, Sam B has had a troubled past and a history of drug and alcohol abuse, and his private life became a haze of fake friends and bad advisers. He believed his gig at Banoi was his last chance to get back on top.

Xian Mei (voiced by Kim Mai Guest), a desk clerk at the Royal Palms Resort. Born and raised by a police commander killed in the line of duty in China, she secretly works as a spy for the Chinese Government. To conceal her covert activities, Xian performs menial tasks for the hotel (as seen in the opening where she helps a sick guest). It is assumed that she does well at keeping her espionage a secret, as all refer to her as the desk clerk. However, during the Jin rescue scene Purna claims that she knows Xian's true nature, and several collectibles show that employees knew she was no ordinary employee.

Logan Carter (voiced by David Kaye), a former American football star, spoiled by life and successful in every possible way. Unfortunately, his own ego finally put an end to his bright future. Taking part in a reckless street race with tragic consequences, Logan not only killed a young woman - his unfortunate passenger - but also fractured his knee, putting an end to his sports career. His fall from stardom inevitably followed and he plunged swiftly into a life of bitterness and despair. He ended up letting a blood drive use his name, and in return received an all-expenses-paid trip to Banoi.

Purna (voiced by Peta Johnson), an Australian Aboriginal former officer of the New South Wales Police Force, referred to by the game as the "Sydney Police department." After losing her career when she shot a child molester (the novelization contradicts this by stating the child molester was killed by her) who could not be prosecuted, due to wealth and connections, Purna then turned to working as a bodyguard for VIPs in dangerous places all over the world. She is mostly hired for her looks (not just her skills), as wealthy men do not mind showing up with Purna on their arm. Purna states she wishes to finish off the child molester after leaving Banoi.

Ryder White (voiced by Joe Hanna), a colonel with the Australian Defense Force who communicates with the hero in Chaos Overture, providing directions for escape. Ryder has also been in contact with the survivors at the Pool House, advising they evacuate to the Lifeguard Tower. When the hero is able to communicate with Ryder once more at the hotel with Dominic, it is revealed that he is on the prison island and is dealing with his injured wife, Emily White. In the "Ryder White Campaign", it is later revealed that Ryder was not the voice from the main game, instead Charon, also known as Kevin, has been posing as him and was the true villain of the game, not Ryder